Tupelo honey is produced in the United States. Bees collect pollen from tupelo flowers that only bloom for a short period each year. This pollen is then turned into honey, which is harvested by beekeepers. Tupelo honey is rare and delicious, but many people may not realize that it also offers health benefits. Here are a few ways you can improve your health using tupelo honey: 1. Soothe the symptoms of the common cold.